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KMID : 0854720100300040285
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 4 p.285 ~ p.292
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Clinical Characteristics of Kimura Disease in Korea
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Kang Min-Koo
Kim Byung-Keun
Kang Sung-Yun
Kim Mi-Young
Lee Seo-Young
Kim Tae-Wan
Lee So-Hee
Kim Sae-Hoon
Kang Hye-Ryun
Chang Yoon-Seok
Kim Sun-Sin
Cho Sang-Heon
Min Kyung-Up
Park Heung-Woo
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Abstract
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Background: The Kimura disease, a chronic inflammatory disorder of unknown etiology, is characterized by subcutaneous mass, regional lymphadenopathy, peripheral blood eosinophilia or increased serum immunoglobulin E level. So far, there has been limited information concerning this disease.
Objective: To investigate clinical features of Kimura disease in Korea.
Method: We retrospectively reviewed 33 patients who had a histologically proven Kimura disease from January 1995 to March 2010 at Hospital. Then clinical features and treatment outcomes were evaluated.
Result: Of all patients, 28 were male (84.8%), and mean age was 25.2±15.1 years. Involved sites were as follows; preauricular (n=8), upper arm (n=8), retroauricular (n=6), submandibular (n=4), eyelid (n=4), inguinal (n=4), and cervical area (n=4). Peripheral blood eosinophilia was observed in 87.1% of patients. Twenty-seven patients were treated by operation, corticosteroids, or radiation, and the other 6 were just followed without any intervention. Among the 27 patients treated, only 12 have achieved a state of control. Treatment outcomes in terms of size and mass numbers were variable.
Conclusion: Kimura disease should be ruled out in young male who shows painless soft tissue swellings with peripheral blood eosinophilia in Korea. The optimal management for Kimura disease needs to be investigated further.
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KEYWORD
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Kimura disease, Eosinophilia, Immunoglobulin E
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